The electric AC compressor is going to be a bit of a faff I'll say that now, but I'm in a similar situation to you where I only need AC for those specific times of year where the weather makes it absolutely essential.
As for the belt you will absolutely need to get a different length belt, your other option is you delete the AC is to put in a dummy pulley in its exact place to maintain the same tension which isn't the worst option, but is just less efficient and takes up much needed space.
In general, lower RPM typically does mean better fuel economy, but with our trucks and their tuning I've found that below 2500-2750 these trucks are tuned really poorly and dump fuel.
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Based on this graph from Da Silva racing from a long time ago, on a mostly stock 3.0. As well as my own driving with a basic OBD2 scanner monitoring fuel volume. This graph is old, and I had to find a lot of the information about the vehicle by reading forum posts, but it's a 3.0 manual, with an indeterminate axle ratio, but combined with other graphs made for the 3.0 vulcan, it shows the fuel mixture leaning out around 2750-3000 just before/during the peak power band.
Generally speaking however I get my best results keeping the truck as low as possible within the given range of 2500-3000 RPM.
Out of the two options you listed, 2200 RPM is probably more efficient, but there's so many other variables you'll get a better answer from doing some fuel economy testing yourself.
If speeding isn't a concern for you, by going a few MpH faster you might actually see some improvement in fuel economy by raising your rpm to the lower side of that range.