My 2002 FX4 has 263K miles on it and still has the original wheel bearings. It is not the tall tires that is hard on the wheel bearings, it is the wheels that have a different offset than stock. I have run 31", 32" and currently 33" tires with the stock Alcoa wheels. I have replaced the ball joints and tie rods in the 150K to 255K miles range, so that is something you may need to do if not done already. I replaced the original Ford tuned Bilstein shocks at around 100K with Bilstein tuned shocks. The fronts have not been replaced since then but I did replace the rear shocks with Bilstein again at around 230 K miles. They were still working but one was starting to seep a little oil. It was still working well and the nitrogen gas pressure was still good but I go on long off-road trip is isolated areas and did not want to deal with a failure there.
I had the transmission checked at around 240K miles and was told 5th gear was worn and needed replacement. Everything else was in good condition, including the synchros. I had them install new bearings and seals along with 5th gear and slider. They unfortunately missed checking the shifter bushings and the bottom one was bad. It eventually failed and caused the 5th gear to wear resulting in it popping out of 5th gear. They did repair it under warranty. So, I suggest you check out the shifter bushings and replace if they show any signs of wear. They are accessible inside the cab without removing the transmission.
I also took the transfer case apart when I had the transmission rebuilt. Everything looked good so I just replaced all the seals. The bearings were still in excellent condition. About 15K miles later the shifter fork broke. It is made of plastic and I may have used too much force shifting it into gear a few times. I don't know if this is a common failure, but I have not heard anyone talk about it.
At 251K miles, one of the precats broke up inside and clogged the first main cat. I ended up replacing the entire catalytic converter system, which was expensive because I need CARB compliant since I live in CA.
I rebuilt the cam timing chain system at around 255K miles. I was not have any problems but wanted to make sure I would not have any problems knowing the guides are suspect. The timing chain guide and tensioner were still in good condition but the mechanical tensioner for the chain between the crank and jackshaft was broken. This seems the be a rarity because I have never heard anyone talk about this tensioner breaking.
Everything else that I have replaced is what I consider normal maintenance.
When I bought my 02 FX4, I intended to keep it 300K miles. It is running so well now that I may keep it longer. I think parts availability will dictate how long I keep it.