With the 2.5 Lima, axle strength won't be an issue. Gear ratio availability is going to be better with the 8.8 over the 7.5. The engine, while reliable is a bit of a dog. I would recommend looking at the gears vs tires chart in the tech library to help decide where you want to be in the power range. From personal experience, 4.10 was a good match for the 27" tires on my 1998 with the 2.5 engine in it. I believe that put it in the best power for towing and hauling section of the chart. Right at the lower edge. Now, I live in the Appalachia Mountain chain with a lot of hills and valleys. If you live in a fairly flat area, you might be ok with a 4.88 vs a 5.13. You will have to be the judge on that since I have no idea what the terrain is like where you live and where you normally drive.
The other side of the equation is fuel economy. If your truck is set up like mine was from the factory with a tall, highway gear (3.45:1), switching to the 4.10 was a zero sum gain. I was burning more fuel than I should have trying to get up to speed and maintaining it with the factory gears that switching to the 4.10:1 gears still gave me about 21-22 mpg instead of the stated 27 or 28 it was supposed to get. If you have 3.73:1 gears in the truck, the swap might net you an mpg drop but you have already swapped tires where I stuck with the stock size. So, you might not see a difference or your mileage might get better.