Assuming 65mph, a 22 inch tire diameter, and a weight of 50 lbs, the kinetic energy is equal to about 2 tons per square inch on a square face impact. BOOM! I did not include calculations concerning gravity acceleration as it dropped from the sky (9.6 feet per second per second squared), or rotationally induced impact traction (after contact push from spinning). That impact estimate only accounts for the tire hitting a non moving object, not the speed of the vehicle moving in the opposite direction (square of the speed, squared - for opposite directional movement). I may be calculating wrong, but I think it is close. If anyone can do better, please do.
Tires will speed up once they are released from compression, as stated earlier. Gyroscopic force will keep the tire headed in one direction, even up an angled incline (or over or through a crash barrier), and cars can drive with three wheels due to gyro effects (engine, wheels and steady straight line movement) for a mile or more. I've seen inflated tires 60 ft up in trees, wheels attached, and seen em bounce 1/8 mile.