Well, I don't know, but this week I took apart an '87 K30 because I'm putting the axle in my 2wd crewcab. The engine is a 454 which is similar to a 460. A Ranger frame in the front is wider than a '73-'87 fullsize frame by about 2", but the Chevy uses a steering box mounted outside the frame rail. So that is step one--use a GM box mounted outside the rail. A 460 doesn't have that big of an oil pan. I think they are just 5 quarts actually. Been a few years since I had one. But it's a 90 degree V motor and not that tall. Still, it's easy to throw away that big damn thing the TTB is bolted to and make your own crossmember. My 2wd has a huge thing with the suspension mounted to it and it has the engine mounts on it as well. The 4x4 has little engine mounts and a seperate little crossmember.
The moral is, if you are doing a swap to a solid axle, it's no problem. Make a pair of mounts that will accept your pads and then in front of them make a cross member to connect them. A Ranger has a heavy enough frame. Boxing it in somewhere my cause it to break because it makes a hard spot. Two distinctly different sections next to each other = failure.
A 460 won't break a Ranger. Even fitting it wouldn't be that bad. People have sort of installed a 300-6 and that's a lot longer.
Better to install a 6.2/6.5 GM diesel with a turbo. Same work as a 460, same mileage as a 4-cylinder Ranger, same power/torque as a 460.