This is very true. There are holes all over these frames that do not cause problems. That does NOT mean you can go drilling holes willy-nilly all over the place. Generally speaking, adding holes in the flanges should be avoided, though it is sometimes necessary. Holes in the web (the big vertical part of the frame) are more acceptable, but should be minimal in size and kept toward the center if possible. Most of the static and dynamic loading of the frame is vertical. So the top and bottom see tensile and compressive stresses. The center of the web sees the least amount of stress. Therefore, that is where holes have the least amount of weakening affect.