Since everyone is talking gears....I will chime in.
I drove for 8 months on 33's and 3.73's in an 4.0L with a auto tranny. 60 miles a day, 90% freeway.
Boy was that stupid ridiculous. I got around 16mpg if I kept the rpms up about 2400 (70-75mhh). 2000 rpms doing the speed limit
Gutluss SOB thats for sure.
Offroad it sucked even more, the truck never had enough power to climb ledges, I would just sit there with my skinny self STANDING on the gas pedal and couldn't do jack.
Then I went to 4.88's and I drive a little slower on the freeway, but its much better. The truck accelerates awesome on freeway ramps, has passing power and towing power. I love it. And I picked up 2mpg (last two tanks I got 338 miles on 18.1 gas @ 65mph). That alone was worth the swap. Now my RPM's are about 2500 at 65mph, and 2800 at 70 mph.
Basically what I am saying is, nothing beats PROPER gearing. Lower RPMs on the freeway does not automatically mean better mileage.
And even though they are more expensive new, I would HIGHLY suggest 4.56's with 33's. 4.10's isn't enough for freeway driving. The 4.0L needs to be revved a little heigher than I think you think it needs to be. 4.56's will give you better mileage, better power, and better torque for wheeling.
Don't be afraid of gearing! Keep your eyes open, I see used 4.56 gearing all the time here in the classifieds. I even think there are some in there now
I think you will be disappointed if you go with 4.10s, might as well do it right the first time right? Cheaper doing it once as opposed to twice
In my mind, you can't go wrong with a set of 4.56's gears, since thats what they reccommend for 33" tires and the 4.0L anyway. Just do it! I'm thinking you could easily do 70 mph, at 2500 RPMs AND get better mileage. At least that's what my numbers suggest.