The more overlap a cam profile has, the more cylinder pressure you are going to bleed off. So not having enough cylinder pressure to start with is a problem. Thus having higher compression helps the situation a lot. Also, the size of the cam is also dependent on what size engine it is in. The more cubic inches, the less the effect the cam has. So a cam that might be large for a 289 or 302 is not too large for a 351. So ging a generic answer to how much duration is the point where more compression is needed is not an exact science. And . . how much compression are you considering stock or low? 9:1 ?? I have run durations in the 220s at .050 easily with 9-9.5 CRs with a 302. If I were to be in the 230s, I would want compression to be about 10:1.