Lil buggers are building nests everywhere around here again this year. It's usually an ongoing battle. Large nests don't seem to be a deterrent at all, had one bigger than a basketball two years ago. Left it up after it was abandoned and it didn't deter any from building elsewhere.
Best bee killer spray I ever used was some stuff called Black Leaf. Of course, I haven't been able to get any for a couple years now...
The worst around here are the mud wasps because they build big mud tubes on anything and everything. I dunno how they do it, but those things are about impossible to clean off - even a scrub brush and soapy water doesn't work very well.
Couple years ago I took down a huge wasp nest for a customer of mine (not my usual line of work). Showed up at the crack of dawn one morning, set up a ladder and from about 3' away I emptied a can of foaming bee spray into the nest. Then I shot down the ladder and had a cup of coffee with the homeowner, lol. Wish I would have got some pictures, thing was about as big as a beach ball. Despite the foaming spray, there were still some survivors, so I put a can of regular spray into things. Next day I started knocking it down and spraying anything that twitched.
A cutting torch works for killing them too, seen that done a couple times at a junkyard. Just a twist of the gas valve and fried bees. Of course, you have to be kinda close....
Another trick I saw at the junkyard involved a fire extinguisher. They had one of those refillable ones, they'd fill it with water and put a little dish soap in, then charge it up off shop air.
When I did concrete construction, we'd use the solvent based sealer in a sealer sprayer. Didn't kill them instantly, but a quick mist of that sealer in the air was like hitting a brick wall for the lil suckers, they'd go right down and then the stuff would harden on them, which would leave them largely unable to move.