A lot of this is scale of things.
I know on a V8 the DS turbo would be in the way of the steering, and on my longer 302 the power steering pump happily lives where the alternator is on the ecoboost. Pushing for all the forward room I could get my 302 is farther back than the 2.8 was too. If the engine would be long enough to dodge the steering gear the alternator would be ok on the EB.
Since it is a 60 degree engine it would be more forgiving than say a 90 degree V8, how much is anybody's guess.
It is a twin turbo, so proximity of the PS turbo to the plastic HVAC box would be important too. A heat gun can be used to reshape it for the valve cover if you need to, it is commonly done for V8 swaps (or you can swap to a non-AC box to open up a ton more room and don't want AC anymore)
A lot of this IMO is going to be in the air until somobody actually tries it. Even a tape measure can lie (it did on the length of my 302 and radiator clearance) and so far we don't even have that to go by.
The 3.7 is another runner that might have fewer complications. I watched one in a Mustang (automatic with 2.xx gears) pound the snot out of two new (LS1 or LS2) GTO's at the local 1/8th mile track a year and a half ago. Since the Ecoboost is only something like $500 more, my local dealer has had enough interest to even order any 3.7 F-150's though. Just Ecoboosts and 5.0's... so they may not be as available in JY's.