You'll have to drain the coolant anyway. You should also siphon out the coolant in the overflow tank and replace it with fresh mixture. After draining the coolant, then change the thermostat, get that resealed, then flush the radiator. Leave the step of adding the new antifreeze mixture until last to make sure you have no leaks.
You probably know how to refill a radiator with coolant, but here's a refresher. Just did this myself a few months ago. Fill the system as much as possible through the radiator, start the engine with heat on (fan low), and top the coolant as the system purges itself of air. Expect this to take at least half an hour of run time, and keep a funnel in place in the radiator-cap neck. After you put as much coolant in as possible and the coolant level in the radiator stops going down, drive the truck as usual, but expect more purging over the next several days. As this happens, the replacement coolant will come from the overflow tank. Keep an eye on the tank and top it as necessary with antifreeze mixture. After a week or so, the level in the tank should stabilize, meaning that the air has been purged.
Hope this helps.