This is the only time that I have to dis-agree with AllenD. If the two pieces are not in contact with each other when tapping, there will be a vast amount of stress on the bolt and with no friction between the two pieces the hole could egg out over time. If you can clamp the two pieces together while tapping then it should be OK. Drilling and using the shank shoulder to fill the hole is easier and as strong, if not stronger IMO.
My right and doesn't work the way it used to so typing is rather tiresome...
But I often tap just tte frame rail, not what I'm bolting to it . There I often use an Aircraft frame reamer (an adjustable reamer) to enlarge the hole in body mount brackets and cross-members to an EXACT FIT of the bolt shank...
I also de-rust all surfaces and coat used to coat them with Zinc Chromate primer (when I still had any available)
Lately I use Aerosol bed-liner.
And like mentioned above I prefer all metal self-locking nuts
Common "Split-lock washers are only slightly better than useless
But while MAC points out that structural steel framing does not use locking nuts
The only structural steel that lives with the vibration of a light truck frame is a structural steel tower
at the Kennedy Space Launch facility, but I'd bet in terms of bolt loosening a Ranger
frame is worse... FAR worse!
As when a launch tower if vibrated it is only for a matter of 15-20 seconds and is then quiet for months
Nobody takes that launch tower out for an afternoon of washboard desert roads...
Or the even across the parking lot of my favorite U-pull-it junkyard
(let alone the 30mile drive (each way) to get there!)
AD