Started with a 351/C4/Dana 20, then a 396stroker/C4/Dana20, then a 396W/ZF/Np205, now going to a maybe bigger than a 396W/C6/203-205doubler. A stock type V8 the frame isn't an issue. More than 450hp then I would start adding some things. As far as headers I used a brand new set of long lubes, a cutoff wheel, a tube bender and a welder.
Matt