This pretty well covers it…
if you really want to try to get the most, have the engine rebuilt with balanced internals and have the intake and heads flow ported. Add headers to the exhaust, e-fan, underdrive pulley setup, electric power steering… wouldn’t be exactly cheap to do all of that, but you’ll pick up some power and fuel economy without getting into the troubled waters of engine swaps that open up cans of worms. The easiest and cheapest swaps are like for like and a few scattered plug-n-play kind, like a 4.0 in place of a 2.9 in 89-92 vintage or 5.0 into 98-00. Or adding a turbo to a 2.3 truck (forget what years were ideal for that, but the donor was a thunderbird or the like for the turbo and wiring).