an He351 (thats from the 24v cummins right?) would be over kill......... would prolly boost enough to blow the head gaskets.....
Maybe with some ARP head studs, steel composite head gaskets, Main studs and a main girdle....... you might be able to boost a 300 I6 to 30psi.
[EDIT] keep in mind I don't know anything about turbo charging a gas engine but I do know a little about diesels and the 300 I6 has a very similar power curve to a diesel. [/EDIT]
Yes, it's the one that is run on the 2005-07 cummins.
I run the he351 on my 2.3 and it hits full boost (up to 30# depending on where I set the WG) at about 3800 RPM. On a motor over twice it's size with a little worse breathing, I would expect it to spool just after 2000 rpm. I think that would be very useable and street friendly. I would set the WG to about 15# and I think you could expect 500 ft/lbs and 350-400 rwhp with a good tune (read: megasquirt). It would likely run really strong from 2000-5000 RPM and then just drop off (assuming you get a mild aftermarket cam).
I've never turboed a 300 (but have wanted to), and this is just me shooting off the hip based on my experience with turbocharging.