lol, I said loose performance, not stop running! but 'ya, we're on the same page.
IDK how to help you right now stockfornow, just have to go through the systems that you know and make sure they are all operating correctly. When's the last time you changed a fuel filter? (If you have the 'cup' style filter use some litium grease on the O-ring to keep it in place, it can be a PITA. (As opposed to the in'line filter))
I felt pretty stupid 2 months ago when I was *almost* out of patience with my 5.0L and I took one of my friends for a cruise and he said "seems like it's starving for fuel" sure enough, the fuel filter was CAKED with dirt. Such an easy fix, but I went through that entire EFI system looking for a problem. I know it reasonably well now because I tested EVERY sensor, found a bad TPS, bad air bypass valve, and a plugged injector, and failed fuel pressure regulator. I do NOT expect you to find more than two problems, the reason mine was in such "awesome" condition is because I got it from the wrecker, and the owner before me didn't know about 'maintenance'.
Start with the stuff you know, if that dosn't do it, then you have to learn enough about your system to tackle the rest of it. Good luck.
Edit: do you know how to check for vacuum leaks? Hint = WD40