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I once had a 2.8 inside my MGB. The motor was blueprinted. A few other small modifications along the way. I remmember that it had headers. It ran just fine with a Holley 2 barrel. I would imagine that a four would require a very fast cam along with some other work. Let us know how it works.
A friend of mine raced with one on a clay track.those small 390 holleys are great. i used it on a 302 and a jeep inline 4.5 stroker. it was perfect for a small displacement engine
Just remember that 4 barrels flowed at 1.5" mercury and 2 barrels are flowed at 3" mercury from the factory. This means that a 2 barrel flows 41% less than you think it does. 2 barrel and 4 barrel flow are not apples for apples.I used an Offenhauser 4 barrel manifold on the 2.8 I swapped into a 64 Sunbeam Alpine for a friend with good results. The smallest Holley 2 barrel flows 350cfm and the smallest 4 barrel flows 390 cfm so the primaries are smaller than the bores on the 2 barrel. I had the heads planed .030"and ported them, installed a small Comp cam and headers but nothing radical, it idled and ran smoothly.
I think your home made 4 barrel manifold will work fine.
Its good someone knows the math, seems like we have too many people that think a 500 2 barrel flows more than a 390 barrel, and dont realize a 4412 is just half of a 750 4 barrel.The primaries on the 390 4 barrel will flow less that the 350 2 barrel and the primaries are used for most driving. I know the math, thanks.