Early S10's have a mechanical speedo (gear), later ones have an electric sender (sends pulses)... don't know the 1986 ford recipient from ~1980's chevy donor differences, but by 1990 they were electric speedo and I put a 1990 S10 T-5 in my 1948 F-1. It worked fine for me cause I was using an aftermarket speedometer that needed electric pulses and was universal, you program the speedometer in the 1st mile for however many pulses you happen to get from any sender. Swapping tailhousing means basically completely tearing down the transmission entirely. Just be aware that the ford mustang variety has the ford "SBF" or"symetric butterfly" bolt pattern and the chevy S10 T-5's have chevy Muncie or MT350 pattern, so making a hybrid is a lot of work no matter how you tear into it. I guess if I was going about it I would hunt down an early S10 with mechanical speedo. Even then you might end up having to buy a chevy to ford speedo cable (if they are different threads, end connectors or whatever). Over on ford-trucks.com in the 1948-56 forum there is tons of tons of info on the T5 swap for them and somewhere buried I bet you can find which year was the cutoff.
I just thought of another solution, but it is more electrical parts and $$$ - aftermarket they make an backwards converter, converts the electric speedo pulses from the trans back into mechanical, I bet you can find it on CJ Pony Parts or Dakota Digital.