As RonD said, e85 is a blend of gasoline, and ethanol. Ethanol is a type of alcohol, so it raises the octane, which reduces pinging, but it also cleans everything that the fuel touches such as lines, injectors, valves and combustion chambers.
It is very important to begin using e85 in smaller amounts if you've never used it before. Over time, gunk builds up inside your fuel system, and the e85 will begin to break that varnish up. If you put an entire tank of e85 in at once, it can break up the 'gunk' too quickly and the particles can clog injectors.
If you choose to use e85, just start with half a tank of regular, and half a tank of e85. Once that tank is empty, you should be able to run a full tank of e85.