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Speed or Cruise control doesn't have a separate fuse in your 2008, its run thru the PCM(engine computer)
Usual causes for cruise to stop working is brake pedal switch or brake pressure switch fault
These are switches that would turn off Cruise control if it was on
So if one of these switches fail then you can't turn it on
I assume brake lights work, this is not the same switch but its part of that same switch
Not familiar with E350 wiring so that's as far as I can go, but for sure its not a fuse issue
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Checked both switches and were ok, reset PCM and every thing back to normal and working
fine. Thank you for putting me on the right path