No, that sounds about right.
The lube pressure only needs to be a couple dozen pounds.
The HP system that runs the fuel injectors needs to be up around 1200 PSI.
Lube oil pressure: 12 psi at 700 rpm, 24 psi at 1,200 rpm and 45 psi at 1,800 rpm with engine at operating temperature
Copied from the D&O section of the 2005 F-250 - 550 6.0L service manual:
The engine uses an electrohydraulic injector as part of its fuel system. This PCM/FICM-controlled injector uses high-pressure lube oil to provide the necessary force to inject fuel into the combustion chamber at pressures up to 21,000 psi at rated horsepower
I couldn't find a high pressure spec, but I know the 6.0 uses HUEI injectors that use high pressure oil to push down on a pintle that acts on an amplification chamber that creates the 21000 PSI fuel pressure and that the HP oil system runs over 1000 PSI.