Is it relatively flat where you live? I would get rid of the 4.10 gears and go with the lowest numbered gear they offered. I do not think you need max efficiency from the engine which would be the most power output for the amount of fuel going in. Thing is, that is way more power than you need at cruising speed.
When researching an electric vehicle, of course it will vary a little bit, but it's generally known that a vehicle needs around 10 hp to maintain 55mph. So you want your truck to barely need any throttle to maintain speed. I have never had one, but have heard the 3.0 does have some use able torque down low.
I am sure you have driven many modern vehicles from the factory. You can tell all the OEM's do it now. When in drive they have engine, whatever engine it is, barely loping along. Any sort of maneuvers by the operator require the transmission to downshift. Thus why they went to the 5, 6, 8, and 10 speed transmissions. They are not doing it because they want to or the car buyers wants the mpg, the government is making them do it.
So on the main build thread, as well as a different post this has been discussed and with the help of the forum we came to some interesting conclusions about engine RPM, and axle ratios on this truck in particular.
I do in fact live in a hilly place, but the main reason I'm not prioritizing installing a lower gear axle is one, cost and time, and two:
This engine is overall built to be inefficient but stupid reliable from Ford, with very low compression and tuned to run super rich particularly at the low end. It's fuel curve finally starts to lean out around 2750, where the truck is in its power band. At first I assumed, as is typically the case that lower RPM = less fuel, and that is somewhat still the case here.
After some fuel economy runs where I kept the engine as low RPM possible over a 400 KM journey, and on then drove the truck with O/D turned off at lower speeds, and driving faster to keep the truck in the "sweet spot" of 2750-3300 RPM, out of the two runs, the faster, higher RPM run yielded better fuel economy results by a noticeable margin.
I could most likely see some benefit by dropping in a tune, or at most 3.73 gears but to go with a lower ratio some more work needs to be done, and a tune needs to be applied. Then I could be in that situation of trying to basically keep my truck at just above idle in final drive for a slower but efficient highway cruising speed, as I used to with my other vehicles.
On the extra speed gears, I will say as someone who hyper miles having extra gearing even though it's typically just more ratios in between what would otherwise be the same 1st and final drive, is actually pretty useful for fuel economy in mixed driving, or carry a load.
I know we all hate CVTs, but genuinely the quick drive I took in a new Prius Prime with it's hybrid and CVT transmission made me really appreciate them as the engine was always in the most efficient place for the task, whether that was coasting or accelerating.